谌文强
学历、职称：博士、副教授/硕士生导师（有机化学）
专业方向 ①有机小分子荧光探针
②超分辨荧光染料
③诊疗一体化有机功能小分子
④高性能光敏剂
电 话：0771-3908065
Email：chenwq@csu.edu.cn
教育与研究经历
2006/09 – 2010/07，东北大学，理学院应用化学系，获理学学士学位
2010/09 – 2015/07，中南大学，化学化工学院有机化学系，获理学博士学位
2015/09 – 2020/11，南宁师范大学，化学与材料学院，讲师
2019/03 – 2020/04，新加坡国立大学，化学系，访问学者
2020.12 – 至今，南宁师范大学，化学与材料学院，副教授
近5年以第一作者或通讯作者在Analytical Chemistry，ACS Sensors, Sensors and Actuators B: Chemical, ACS Chem. Neurosci.等国外著名SCI期刊上发表论文30余篇，其中中科院分区一区论文15篇，论文累计他引1000余次，其中单篇论文最高他引178次，单篇他引>100次论文3篇。目前主持和参与国家和省部级项目11项。受邀为Chemical Engineering Journal, ACS Sensors, Analytical Chemistry, Sensors and Actuators B: Chemical; Analytical Chimica Acta等多种国际SCI学术期刊评审相关稿件。
承担项目与课题
1、国家自然科学基金地区项目，22368035，多种动脉硬化标志物顺序响应型探针的构建及精准成像应用研究，2024/01-2027/12，32万，在研，主持。
2、国家自然科学基金青年项目，22108127，原生Zn2+激活型ONOO-前体探针的构建及其用于胰腺β细胞内ONOO-的精准成像研究，2022/01-2024/12，30万元，在研，主持。
3、国家自然科学基金地区项目，21968019，能同时区分检测HClO，ONOO-和HClO/ONOO-的线粒体靶向型吩噻嗪罗丹明染料的设计、合成与生物应用，2020/01-2023/12，40万元，结题，主持。
4、中央引导地方科技发展资金项目，桂科ZY23055019，多种动脉硬化标志物顺序响应型探针的构建及其精准成像应用，2023/09-2026/09，20万，在研，主持。
5、国家自然科学基金地区项目，22065026，能同时区分检测多种活性氧分子的聚合物纳米探针研发，2022/01-2024/12，41万元，在研，参与。
6、国家自然科学基金地区项目，22368036，PDT疗效系统增强型硫代尼罗蓝光敏剂的构建及其抗恶性实体瘤研究，2024/01-2027/12，32万，在研，参与。
7、广西自然科学基金青年科学基金项目，2016GXNSFBA380229，具有大Stokes位移的近红外罗丹明染料的设计、合成与应用，2016/09-2019/08，已结题，主持。
8、广西自然科学基金面上项目，2017GXNSFAA198342，“响应模式可调控”的新型过氧化氢荧光探针的构建，2017/09-2020/09，12万元，已结题，主持。
9、国家自然科学基金地区项目，21761006，酞菁敏化Ru-arene配合物的PCT抗肿瘤研究，2018/01-2021/12，38万元，在研，参加。
10、广西自然科学基金青年基金项目，2016GXNSFBA380123，具有高水溶性、低毒性的 TBET 比率型荧光探针体系的构建及其细胞成像应用研究，5万元，已结题，参与。
11、广西自然科学基金回国基金项目，2016GXNSFBA380013，双功能姜黄色素敏化 Cp*-Ir 配合物的 PDT 抗肿瘤活性及其作用机制研究，10万元，已结题，参与。
个人获奖
1. 广西高校青年教师教学能手
2. 第九届广西高校青年教师教学竞赛一等奖
3. 第八届广西高校青年教师教学竞赛二等奖
4. 南宁师范大学科研先进个人
主要学术论文（*通讯作者）
2024年
1. Wenqiang Chen*, Wenju Xu, Jiayi Xing, Qixuan Liu, Jinshuai Wang, Meijun Meng, Jiarong Sheng*, Qi Xiao*, Lintao Zeng and Lei Yang, De novo design of highly stable ratiometric probe for long-term continuous imaging of endogenous HClO burst, Anal. Chem. 2024, Doi: doi.org/10.1021/acs.analchem.3c05056. (SCI 一区)
2023年
1. Zhipeng Chen, Lei Yang, Wenju Xu, Feifei Xu, Jiarong Sheng,* Qi Xiao,* Xiangzhi Song, and Wenqiang Chen,* Homoadamantane-Fused Tetrahydroquinoxaline as a Robust Electron-Donating Unit for High-Performance Asymmetric NIR Rhodamine Development, Anal. Chem. 2023, 95, 3325-3331. (SCI 一区)
2. Wenju Xu, Zeqiang Li, Dayou Tan, Qixuan Liu, Shuxing Su, Yudi Chen, Lei Yang, Jiarong Sheng,* Qi Xiao,* Wenqiang Chen,* Intracellular biothiols assisted triple-channel imaging of mitochondrial HClO in living cells, Sensors and Actuators B: Chemical, 2023, 393, 134304. (SCI 一区)
2022年
1. Peng Hou, Guofang Li, Zeqiang Li, Liling Yue, Likun Liu, Jingwen Sun, Haijun Wang, Wenqiang Chen, Xiangzhi Song, Song Chen,* A robust dual-channel fluorescence-enhanced probe for duplex imaging of endogenous HClO/ClO- in living cells and in zebrafish, Sensors and Actuators B: Chemical, 2022, 359, 131562. (SCI 一区)
2021年
1. Jiali Chen, Yao Lu, Yue Wu, Zhipeng Chen, Xingjiang Liu, Chengwu Zhang,* Jiarong Sheng,* Lin Li, Wenqiang Chen,* and Xiangzhi Song, De Novo Design of a Robust Fluorescent Probe for Basal HClO Imaging in a Mouse Parkinson’s Disease Model, ACS Chem. Neurosci. 2021, 12, 4058-4064. (SCI二区)
2020年
1. Xiaojie Ren, Fan Zhang, Hongchen Luo, Lide Liao, Xiangzhi Song* and Wenqiang Chen*, Red-emitting boron difluoride complexes with Mega-large Stokes shift and unexpectedly high fluorescent quantum yield, Chem. Commun., 2020, 56, 2159-2162. (SCI二区, IF: 5.996, 他引: 10 次)
2. Li Fu, Chunfei Chen, Wenqiang Chen*, Jun Huang, Junan Xiao, Lei Yang*, Jiarong Sheng* and XiangzhiSong, The unique substitution-cyclization reaction cascade inspired highly selective H2Sn probe development, Sens. Actuators B, 2020, 304, 127382. (SCI 一区, IF: 7.1, 他引: 2 次)
3. Hui Zhang, Wenxiu Li, Jiali Chen, Guofang Li, Xiuxiu Yue, Liangliang Zhang, Wenqiang Chen* and Xiangzhi Song*, Simultaneous detection of Cys/Hcy and H2S through distinct fluorescence channels. Anal. Chim. Acta, 2020, 1097, 238-244. (SCI二区, IF: 5.977, 他引: 1 次)
4. Wenqiang Chen*, Guofang Li, Chunfei Chen, Jiarong Sheng and Lei Yang*, Aggregation-enhanced emission enables phenothiazine coumarin as a robust ratiometric fluorescent for rapid and selective detection of HClO, Spectrochim. Acta A, 2020, 228, 117724. (SCI二区, IF: 3.232, 他引: 1 次)
5. Qian Fang, Lei Yang, Haiqing Xiong, Shaohui Han, Yun Zhang, Jingpei Wang, Wenqiang Chen* and Xiangzhi Song*, Coumarinocoumarin-based fluorescent probe for the sensitive and selective detection of hydrazine in living cells and zebra fish, Chinese Chem. Lett., 2020, 31, 129-132. (SCI二区, IF: 4.632, 他引: 0 次)
6. Jinyan Gai, Chunfei Chen, Jun Huang*, Jiarong Sheng*, Wenqiang Chen* and Xiangzhi Song, An acetophenothiazine-based fluorescence probe for multi-channel imaging of thiophenol with a large Stokes shift, Tetrahedron Lett., 2020, 61, 152038. (SCI三区，IF：2.651, 他引：1次)
2019年
1. Hui Zhang, Lizhen Xu, Wenqiang Chen*, Jun Huang, Chusheng Huang, Jiarong Sheng, and Xiangzhi Song, Simultaneous Discrimination of Cysteine, Homocysteine, Glutathione, and H2S in Living Cells through a Multi-signal Combination Strategy, Analytical Chemistry, 2019, 91, 1904-1911 (SCI一区，IF：6.042，他引：46次）
2. Wenxiu Li, Simin Zhou, Liangliang Zhang, Zhengmin Yang, Hua Chen, Wenqiang Chen*, Jiangke Qin, Xingcan Shen, Shulin Zhao, A red emitting fluorescent probe for sensitively monitoring hydrogen polysulfides in living cells and zebrafish, Sensors and Actuators B: Chemical, 2018, 258: 125-132 (SCI一区，IF：5.667, 他引：21次)
3. Hui Zhang, Jiali Chen, Haiqing Xiong, Yun Zhang, Wenqiang Chen*, Jiarong Sheng and Xiangzhi Song, An endoplasmic reticulum-targetable fluorescent probe for highly selective detection of hydrogen sulfide, Org. Biomol. Chem., 2019, 17, 1436-1441 (SCI三区，IF：3. 423，他引：7次）
4. Hui Zhang, Lizhen Xu, Wenxiu Li, Wenqiang Chen*, Qi Xiao, Jun Huang, Chusheng Huang, Jiarong Sheng, and Xiangzhi Song, A lysosome-targetable fluorescent probe for the simultaneous sensing of Cys/Hcy and GSH from different emission channels, RSC Advances, 2019, 9, 7955-7960 （SCI三区，IF：3.108，他引：6次）
2018年
1. Hui Zhang, Lizhen Xu, Wenqiang Chen, Jun Huang, Chusheng Huang, Jiarong Sheng, and Xiangzhi Song Hui Zhang, Lizhen Xu, Wenqiang Chen*, Jun Huang, Chusheng Huang, Jiarong Sheng, and Xiangzhi Song, A Lysosome-Targetable Fluorescent Probe for Simultaneously Sensing Cys/Hcy, GSH, and H2S from Different Signal Patterns, ACS Sensors 2018, 3, 2513-2517 (SCI一区，IF：7.333, 他引：56次)
2. Xiuxiu Yue, Wenxiu Li, Wenqiang Chen*, Liangliang Zhang*, Guofang Li, Zhang Hui, Xiangzhi Song and Jiarong Sheng*, A dual-response naphthofluorecein-based fluorescent probe for multiple-channel imaging of cysteine/homocysteine in living cells, Tetrahedron Letters, 2018, 59: 2232-2237 (SCI三区，IF：2.125, 他引：0次)
3. Long He, Xingjiang Liu, Yun Zhang, Lei Yang, Qian Fang, Yani Geng, Wenqiang Chen*, Xiangzhi Song*, A mitochondria-targeting ratiometric fluorescent probe for imaging hydrogen peroxide with long-wavelength emission and large Stokes shift, Sensors and Actuators: B. Chemical 2018, 276, 247-253 (SCI一区，IF：5.667, 他引：28次)
4. Wenqiang Chen*, Xiuxiu Yue, Jiarong Sheng, Wenxiu Li, Liangliang Zhang, Wei Su, Chusheng Huang, Xiangzhi Song, Rational development of a highly selective ratiometric fluorescent probe for hydrogen polysulfides, Sensors and Actuators B: Chemical, 2018, 258: 125-132 (SCI一区，IF：5.667, 他引：3次)
2017年
1. Wenqiang Chen*, Xiuxiu Yue, Hui Zhang, Wenxiu Li, Liangliang Zhang, Qi Xiao, Chusheng Huang, Jiarong Sheng*, Xiangzhi Song, Simultaneous Detection of Glutathione and Hydrogen Polysulfides from Different Emission Channels, Analytical Chemistry, 2017, 89(23): 12984-12991（SCI一区，IF：6.042，他引：42次）
2. Wenqiang Chen*, Xiuxiu Yue, Wenxiu Li, Yuanqiang Hao, Liangliang Zhang, Linlin Zhu, Jiarong Sheng*, Xiangzhi Song, A phenothiazine coumarin-based red emitting fluorescent probe for nanomolar detection of thiophenol with a large Stokes shift, Sensors and Actuators B: Chemical, 2017, 245: 702-710 (SCI一区，IF：5.667, 他引：50次)
3. Wenqiang Chen*, Linlin Zhu , Yuanqiang Hao , Xiuxiu Yue , Jinyan Gai ,Qi Xiao , Shan Huang , Jiarong Sheng*, Xiangzhi Song, Detection of thiophenol in buffer, in serum, on filter paper strip, and in living cells using a red-emitting amino phenothiazine boranil based fluorescent probe with a large Stokes shift, Tetrahedron, 2017, 73(31): 4529-4537 (SCI三区，IF：2.651, 他引：10次)
2016年
1. Wenqiang Chen, Hongchen Luo, Xiangjiang Liu, James Walter Foley, Xiangzhi Song*, A broadly applicable strategy for the fluorescence based detection and differentiation of glutathione and cysteine/homocysteine: demonstration in-vitro and in-vivo, Analytical Chemistry, 2016, 88(7): 3638-3646（SCI一区，IF：6.042, 他引:118次）
2015年及以前
1. Wenqiang Chen, Qian Fang, Dalei Yang, Hongyan Zhang, Xiangzhi Song*, James Foley, A selective, highly sensitive fluorescent probe for the detection of sulfur dioxide derivatives in aqueous and biological environments, Analytical Chemistry, 2015, 87(1): 609-616（SCI一区，IF：6.042, 他引:120次）
2. Wenqiang Chen, Song Chen, Bingjiang Zhou, Hongbo Wang, Xiangzhi Song*, Hongyan Zhang*, Highly selective red-emitting H2S fluorescent probe with a large Stokes shift, Dyes and Pigments, 2015, 113: 596-601（SCI二区，IF：3.767, 他引:12次）
3. Wenqiang Chen, Xingjiang Liu, Song Chen, Xiangzhi Song* and Jian Kang*, A real-time colorimetric and ratiometric fluorescent probe for rapid detection of SO2 derivatives in living cells based on a near-infrared benzopyrylium dye, RSC Advances, 2015, 5(32): 25409-25415（SCI三区，IF：3.108, 他引:21次）
4. Wenqiang Chen, Hongchen Luo，Xingjiang Liu，Fengpei Qi，Dalei Yang, Xiangzhi Song*, A fluorescent probe emitting in near-infrared region for sensitive and selective detection of biothiols in both solution and living cells, Tetrahedron Letters, 2015, 56(52): 7176-7179（SCI三区，IF：2.125, 他引:7次）
课题组合影
欢迎报考本课题组研究生（每年招收3-4位学术型研究生）！
