肖军安

学历、职称：博士、副教授（硕士生导师）

专业方向：过渡金属催化不对称合成

联系方式：jaxiao@nnnu.edu.cn

教育与研究经历

2008.9-2012.7 ：湖南科技学院，化学专业，获理学学士学位

2012.9-2017.6 ：中南大学，有机化学专业，获理学博士学位，导师：阳华 教授

课题组主要从事过渡金属催化不对称合成研究，聚焦合成化学领域新方法、新试剂和新策略。近年来在过渡金属催化不对称合成及有机硒化学等领域取得了一系列重要进展，以第一作者或通讯作者身份在Organic Letters、Science China Chemistry、Chemcal Communications、Organic Chemistry Frontiers、The Journal of Organic Chemistry等杂志发表高水平SCI论文23篇，合作论文40余篇，授权国家发明专利5项，转让发明专利1项，专利产品“1,2-二溴-3-丙胺盐”系列产品已通过药明康德旗下览博网及百灵威商品化。先后主持在研及完成国家自然科学基金2项，广西自然科学基金2项，广西科技厅项目1项，广西教育厅项目1项。

教学情况

主讲本科生专业基础课《有机化学》和专业选修课《有机合成》以及研究生《高等有机化学》。指导本科生累计获得国家级大学生创新创业项目1项，自治区级大学生创新创业项目5项；指导本科生获得广西高校大学生化学化工类学术论文竞赛二等奖1项，三等奖2项，获得广西区“挑战杯”大学生创新创业大赛获二等奖1项。

承担项目与课题

(1) 国家自然科学基金地区基金项目，“基于双金属调控的环丙烷-炔烃双位点不对称环化反应研究，项目编号：22261036，33万，主持，在研。

(2) 国家自然科学基金地区基金项目，““边臂”强化三蝶烯膦配体的设计合成及其在催化不对称构建氧化吲哚螺环中的应用”，项目编号：21861008，40万，主持，已结题。

(3) 广西自然科学基金面上项目，“基于Au/M双金属体系的炔基环丙烷不对称开环-环化反应构建七元环衍生物研究”，项目编号：2021GXNSFAA220121，10万，主持，在研。

(4) 广西科技厅青年创新人才专项，“有机硒试剂的设计、合成及其在硒化反应中的应用”，项目合同编号：桂科AD19245049，10万，主持，已结题。

(5) 广西自然科学基金青年基金项目，“金属-有机双功能催化剂的功能导向合成与不对称催化应用”，项目编号：2018GXNSFBA138037，10万，主持，已结题。

(6) 广西高校中青年教师基础能力提升计划项目，“新型胍类多氢键有机催化剂的合成及其不对称催化应用”，项目编号：2018KY0364，3万，主持，已结题。

(7) 南宁师范大学博士科研启动经费，18万，主持，已结题。

主要学术论文（* 通讯作者）

2023年

[1] J.-A. Xiao,^(*) H. Zhang, X. Luo, R. Meng, W. Wang, W. Lu, W. Su, C. Lin, P. Xia and H. Yang, Diastereoselective Access to Seven-Membered Benzosultams via Palladium-Catalyzed Ring-Opening [3 + 2]-Annulation, Org. Lett., 2023, 25, 4145-4149.

[2] J.-A. Xiao,^(*) R. Meng, X. Shi, X. Luo, H. Zhang, W. Wang, P. Xia,^(*) C. Lin and W. Su,^(*) Palladium-catalyzed [4 + 3]-annulations of oxotryptamines with allyl dicarbonates: an approach toward spiro[azepane-4,3′-oxindoles], Org. Chem. Front., 2023, 10, 4593-4597.

2022年

[1] J.-A. Xiao,^(*) J.-S. Liang, H. Zhang, R.-F. Meng, W. Su, C. Lin, J.-G. Cui and Y. Huang, Solid‐State Direct Electrophilic Selenocyanation of (Hetero)Arenes using Mechanochemistry, Eur. J. Org. Chem., 2022, 2022, 68-71.

[2] Y. Huang, Z. Peng, M. Wei, L. Pang, Y. Cheng, J.-A. Xiao,^(*) C. Gan and J. Cui,^(*) Straightforward synthesis of steroidal selenocyanates through oxidative umpolung selenocyanation of steroids and their antitumor activity, The Journal of Steroid Biochemistry and Molecular Biology, 2023, 225, 106203.

[3] J.-A. Xiao,^(*) H. Peng, H. Zhang, R.-F. Meng, C. Lin, W. Su and Y. Huang, Synergistic Sc(III)/Au(I)-Catalyzed Dearomative Spiroannulation of 2-(Ethynyl)aryl Cyclopropanes with 2-Aryl Indoles, Org. Lett., 2022, 24, 8709-8713.

2021年

[1] J.-A. Xiao,^(*) J.-L. Li, X.-L. Cheng, K. Chen, H. Peng, W.-Q. Chen, W. Su, Y.-M. Huang,^(*) H. Yang,^(*) Enantioselective formal [3+2]-cycloadditions to access spirooxindoles bearing four contiguous stereocenters through synergistic catalysis. Chem. Commun. 2021, 57, (36), 4456-4459.

[2] J.-A. Xiao,^(*) H. Peng, J.-S. Liang, R.-F. Meng, W. Su, Q. Xiao,^(*) H. Yang,^(*) Gold/scandium bimetallic relay catalysis of formal [5+2]- and [4+2]-annulations: access to tetracyclicindole scaffolds. Chem. Commun., 2021,57, 13369-13372.

[3] X.-Z. Zheng, K. Chen,^(*) J.-A. Xiao,^(*) J. Li, S.-S. Wang, Q.-L. Zhao, H.-Y. Xiang, X.-Q. Chen, H. Yang^(*), Unveiling the abnormal effect of temperature on enantioselectivity in the palladium-mediated decabonylative alkylation of MBH acetate. Org. Chem. Front., 2021,8, 5058-5063.

[4] J.-A. Xiao,^(*) X.-L. Cheng, H. Peng, J.-S. Liang, X.-Y. Luo, W. Su, Diastereoselectivity-Switchable Gold-Catalyzed Formal [3+2]-Cycloadditions of N-2,2,2-Trifluoro- ethylisatin Ketimines with Yne−Enones. Chem. Asian J. 2021, 16, (17), 2435-2438.

[5] J.-A. Xiao,^(*) H. Peng, J.-S. Liang, X.-Y. Luo, X.-L. Cheng, W. Su, Gold‐Catalyzed Tandem Cycloisomerization/Ring Expansion of Alkynyl Spiro-epoxyoxindoles: Access to Furo[2,3-c]quinolinone Derivatives. Asian J. Org. Chem. 2021, 10, 1436-1439.

2020年

[1] J.-A. Xiao,^(*) X.-L. Cheng, H. Peng, J.-L. Li, Z.-Z. Xie, W.-Q. Chen, Z.-P. Liu, Q. Xiao, W. Su,^(*) H. Yang,^(*) Catalyst-controlled diastereoselective ring-opening formal [3+2]-cycloadditions of arylvinyl oxirane 2,2-diesters with cyclic N-sulfonyl imines. Sci. China Chem. 2020, 63, (6), 785-791.

[2] J.-A. Xiao,^(*) X.-L. Cheng, R.-F. Meng, X.-S. Qin, H. Peng, J.-W. Ren, Z.-Z. Xie, J.-G. Cui, Y.-M. Huang,^(*) Straightforward Synthesis of 3-Selenocyanato-Substituted Chro- mones through Electrophilic Selenocyanation of Enaminones under Grinding Conditions. Synthesis 2020, 53, (05), 954-960.

[3] J. Cui, M. Wei, L. Pang, J.-A. Xiao^(*), C. Gan, J. Guo, C. Xie, Q. Zhu, Y. Huang^(*), Oxidative umpolung selenocyanation of ketones and arenes: An efficient protocol to the synthesis of selenocyanates, Tetrahedron, 2020, 10, (76), 130978-130982.

2019年

[1] J.-A. Xiao,^(*) Y.-C. Li, X.-L. Cheng, W. Chen, J.-G. Cui, Y.-M. Huang, J. Huang, Q. Xiao, W. Su,^(*) H. Yang^(*), Selenocyanobenziodoxolone: a practical electrophilic selenocyanation reagent and its application for solid-state synthesis of α-carbonyl selenocyanates. Org. Chem. Front. 2019, 6, (12), 1967-1971.

[2] J.-A. Xiao, Y.-C. Li, Z.-J. Luo, X.-L. Cheng, Z.-X. Deng, W.-Q. Chen, W. Su^(*), H. Yang. Construction of Bispirooxindole Heterocycles via Palladium-Catalyzed Ring-Opening Formal [3 + 2]-Cycloaddition of Spirovinylcyclopropyl Oxindole and 3-Oxindole Derivatives. J. Org. Chem., 2019, 84(4): 2297-2306.

[3] J.-A. Xiao, X.-L. Cheng, Y.-C. Li, Y.-M. He, J.-L. Li, Z.-P. Liu, P.-J. Xia, W. Su^(*), H. Yang^(*). Palladium-catalysed ring-opening [3 + 2]-annulation of spirovinylcyclopropyl oxindole to diastereoselectively access spirooxindoles. Org. Biomol. Chem., 2019, 17(1): 103-107.

[4] Z.-P. Liu,^(*) J.-L. Li, X.-L. Cheng, J.-G. Cui, Y.-M. Huang, C.-F. Gan, W. Su, J.-A. Xiao,^(*) Visible-Light-Induced Ring-Opening of Hydrogenolysis Spirocyclo- propyl Oxindoles Through Photoredox Catalysis. Eur. J. Org. Chem. 2019, 2019, (25), 4085-4088.

2017年

[1] S.-S. Wen,^# Z.-F. Zhou,^# J.-A. Xiao,^# J. Li, H.-Y. Xiang, H. Yang,^(*) Facile oxidative cyclization to access C2-quaternary 2-hydroxy-indolin-3-ones: synthetic studies towards matemone. New J. Chem. 2017, 41, (20), 11503-11506.

2017年以前

[1] Jun-An Xiao, Peng-Ju Xia, Xing-Yu Zhang, Xiao-Qing Chen^(*), Guang-Chuan Ou, Hua Yang^(*), Amide-assisted intramolecular [3+2] annulation of cyclopropane ring-opening: a facile anddiastereoselective access to the tricyclic core of (±)-scandine, Chem. Commun., 2016, 52(10): 2177~2180.

[2] Jun-An Xiao, Jie Li, Peng-Ju Xia, Zhao-Fang Zhou, Zhao-Xu Deng, Hao-Yue Xiang^(*), Xiao-Qing Chen, Hua Yang^(*), Diastereoselective Intramolecular [3 + 2]-Annulation of Donor-Acceptor Cyclopropane with Imine-Assembling Hexahydropyrrolo [3,2-c]quinolinone Scaffolds, J. Org. Chem., 2016, 81(22): 11185~11194.

[3] Jun-An Xiao, Hong-Gang Zhang, Shan Liang, Ji-Wei Ren, Hua Yang^(*), Xiao-Qing Chen^(*), Synthesis of Pyrrolo(spiro-[2.3']-oxindole)-spiro-[4.3'']-oxindole via 1,3-Dipolar Cycloaddition of Azomethine Ylides with 3-Acetonylideneoxindole, J. Org. Chem., 2013, 78(22): 11577~11583.

[4] Jun-An Xiao^(#), Qi Liu^(#), Ji-Wei Ren, Jian Liu, Rich G Carter, Xiao-Qing Chen^(*), Hua Yang^(*), Highly Enantioselective Construction of Polycyclic Spirooxindoles by Organocatalytic1,3-Dipolar Cycloaddition of 2-Cyclohexenone Catalyzed by Proline-Sulfonamide, Eur. J. Org. Chem., 2014, 2014(26): 5700~5704.

[5] Jun-An Xiao, Chao-Ming Wang, Jing Wang, Guang-Chuan Ou, Xing-Yu Zhang, Hua Yang^(*), Highly stereoselective synthesis of novel spiroimidazolidinones directed by pyridineprolinamide, Tetrahedron, 2015, 2015(1): 805~812.