黄燕敏
学历、职称:博士生/兼职博士生导师
研究方向 :药物合成 有机合成 纳米农药
专业方向:有机化学
联系方式:联系电话:13977159868, 电子邮箱:huangyanmin828@163.com
教育与研究经历
教育经历
1991/9–1995/7,兰州大学,有机化学,学士
2001/9–2004/7,广西师范学院(现南宁师范大学),有机化学, 硕士
2008/9–2011/12,中山大学,有机化学,博士
2012/5-2015/11,美国克利夫兰州立大学访学
1995/7-至今,南宁师范大学,化学与材料学院,教授
(简介)长期从事甾体化合物结构修饰及生理活性研究、具有抗肿瘤活性甾体化合物的作用机制研究、高效新型农药的研发工作。以第一作者或通讯作者在Chemcal Communications、Organic Chemistry Frontiers、Advanced Synthesis & Catalysis、Tetrahedron、Steroids、Bioorg. Med. Chem. Lett.等国际刊物上以第一作者或通讯作者发表SCI论文60多篇。获国家授权发明专利16项。2004 年参与完成的科研成果“具有抗肿瘤活性多羟基甾醇的合成 研究” 获广西科技进步三等奖(排名第五); 2011年作为主要完成人参与的“具有抗肿瘤活性甾体硫酸酯钠盐及肟类化合物的合成及抗肿瘤活性评估” 在2011 年获广西自然科学奖二等奖(排名第二);2016 年,作为第一完成人完成的项目“具有扩环及缩环甾核结构甾体化合物作为抗肿瘤药物的合成和评估”获得广西自然科学奖三等奖。主持国家级、省级及各类项目10余项,2013年入选广西高等学校优秀中青年骨干教师培养工程第二期培养对象、2015年入选广西中青年科技工作者、2017年入选广西“十百千”人才工程第二层次人选、2020年入选广西高校卓越学者。
教学情况
“有机化学”国家一流专业负责人,主讲“有机化学”“有机化学实验”“有机合成”本科生及研究生课程。
荣誉称号
(1)2020年入选广西高校卓越学者
(1)2017年获第二十批广西“十百千”人才工程第二层次人选
(2)2015年获第十三届广西青年科技奖入选者
(3)2013入选广西高等学校优秀中青年骨干教师培养工程
(4)2014广西师范学院学科带头人
(5)2015年度广西师范学院科研工作先进个人
承担项目与课题
(1)国家自然科学基金地区基金项目,22267016,基于植物内源性高分子材料非内吸性农药纳米制剂的内吸传导性研究,2023/01-2026/12,33万元,在研,主持;
(2)国家自然科学基金地区基金项目,21462009,具有特殊甾核结构甾体杂环化合物的设计合成及生物活性评估, 2015/01-2018/12,50万元, 已提交结题报告,主持;
(3)广西重点研发项目,桂科AB21220015, 绿色环保物理作用机制(窒息)害螨灭杀剂的研究开发,135万,在研,主持;
(4)广西创新发展专项(科技重大专项)项目(子课题一),环保控释农药的制备技术研究与产业化,113.4万元,在研,主持;
(5)广西自然科学基金面上项目,2018JJA120087,新型甾体硒杂环化合物的设计、合成及生理活性研究,2019.1-2011.12,12万,在研,主持;
(6)南宁市科技开发项目,20171125-5,广西甾体药物生物工程技术研究中心建设,2017/1- 2018/12, 30万元,在研,主持;
(7)广西自然科学基金项目,2014GXNSFAA118052,北部湾海洋生物中靶向 Src 新型抗肿瘤药物先导的识别及结构优化,2014/06-2017/05, 5万元,结题,主持;
(8)南宁市科技开发项目,20145203,提高无内吸性农药药效及导向剂技术开发,2015.03-2017.03,结题,主持;
(9)广西高等学校科研项目,201202ZD059,抗肿瘤甾体金属配合物的合成及生理活性研究,2012.03-2014.03, 7万元,结题,主持;
(10)南宁市科技开发项目,20131091,蔗糖硫酸酯金属盐作为杀菌消毒液,抗菌剂及抗菌材料的研发,2013.01-2014.12, 25万元,结题,主持;
(11)南宁市科技开发项目,20131091,蔗糖硫酸酯金属盐作为杀菌消毒液,抗菌剂及抗菌材料的研发,2013.01-2014.12, 25万元,结题,主持;
(12)广西自然科学基金项目,2010GXNSFA013052,海洋生物活性分子的改性和应用—甾合铂配合物的合成及生理活性研究,2010.03-2013.03,4万元,结题,主持8.横向课题,具有内吸性农药的合成,2014/1-2016/1,6万元,结题,主持;
(13)广西高等学校优秀中青年骨干教师培养工程(第一期),2013.12- 2016.12,18万。
(14)国家自然科学基金地区基金项目,21562007, B-Nor甾体化合物抗肿瘤机制及药物靶点的研究,2016.01-2019.12,40万元,在研,参加;
(15)广西自然科学基金项目,2010GXNSFD013019,甾体内酰胺化合物的合成、表征及抗肿瘤活性研究,2010.03-2013.03,结题,参加;
(16)国家自然科学基金地区基金项目,20562001,海洋生物中具有抗肿瘤和抗病毒活性的多羟基甾醇及其硫酸酯钠盐的合成和它们的构效关系研究2006.01- 2008.12,20万,结题,参加;
学术成果
(一)主要学术论文(* 通讯作者)
[1]Yanmin Huang, Zining Peng, Meizhen Wei, Liping Pang, Yang Cheng, Jun-An Xiao,* Chunfang Gan, Jianguo Cui,* Straightforward synthesis of steroidal selenocyanates through oxidative umpolung selenocyanation of steroids and their antitumor activity. J. Steroid. Biochem., 2023,225,106203.
[2]Yanmin Huang, Zining Peng, Meizhen Wei, Chunfang Gan, Yuanfei Zhang, Sijing Chen, Junan Xiao, Jianguo Cui. Synthesis and Antiproliferative Evaluation of Some Novel Estradiol Selenocyanates, Steroids, 2022, 181,108992.
[3]Yanmin Huang, Yong Chen, Qipeng Xiong, Yanhong Hu, Xiangying Li, Chunfang Gan, Yuanfei Zhang, Jianguo Cui. Fabrication and evaluation of indoxacarb nano-formulation based on corn starch esters with systemic translocation, Starch, 2022, 74,7-8,202256.
[4]Linlin Wang, Qiang Hu, Yanmin Huang*, Qipeng Xiong, Yong Chen, Chunfang Gan, Yuanfei Zhang, Guoqin Cui, Jianguo Cui. Study on the preparation of sustained-release thiamethoxam microspheres by blending microcrystalline wax with tapioca starch ester or dehydroabietic acid ester as the matrix, J. Environ. Sci. Heal. B., 2022, 57(7), 576-587.
[5]Yanmin Huang, Xiangying Li, Qipeng Xiong, Yong Chen, Zining Peng, Jinghong Chen, Junyan Li, Yuanfei Zhang, Jianguo Cui, Preparation and Insecticidal Activity Evaluation of Emamectin-Lignin Sulfonic Acid Conjugate with Anti-photolysis Property, ACS Omega., 2022, 7,33.29046-29053.
[6]Yanmin Huang, Meizhen Wei, Zining Peng, Yang Cheng, Yuanfei Zhang, Junyan Li, Junan Xiao, Chunfang Gan, Jianguo Cui. Synthesis of Estrone Selenocyanate Compounds, Anti-tumor Activity Evaluation and Structure-activity Relationship Analysis, Bioorgan. Med. Chem. (2022).
[7]Yanmin Huang, Zining Peng, Meizhen Wei, Liping Pang, Yang Cheng, Jun-An Xiao,* Chunfang Gan, Jianguo Cui,* Straightforward synthesis of steroidal selenocyanates through oxidative umpolung selenocyanation of steroids and their antitumor activity. J. Steroid. Biochem., 2023,225,106203.
[8]Yanmin Huang, Xiangying Li, Dongmei Mo, Haiyan Yuan, Qiang Hu,
Yang Jiang, Chunfang Gan, Yong Chen, Weiguo Li, Rui Lu, and Jianguo Cui, Fabrication and evaluation of Lambda-Cyhalothrin nanosuspoemulsion with pH- and temperature-responsive based on polyethylene wax as carrier,J. Environ. Sci. & Health, Part B, 2021,56(8):741-752.
[9]Yimiao He,* XueXue Chang, Zhongfu Su, Kun Liu, Yanmin Huang,* Chusheng Huang, Jian Lei* and Qiang Zhu, Tunable Synthesis of Chalcophosphinic Amides and Tertiary Phosphinates Using tert-Butyl N, N-Dialkylperoxyamidate, Org. Chem. Front., 2021, 8, 4860.
[10]Yuan Chen, Rui Yu,Min Wang,Yanmin Huang,*Yungui Peng, Enantioselective 1,6-Conjugate Addition of Dialkyl α-Diazo Methylphosphonateto para-Quinone Methides,Adv. Synth. Catal. 2021, 363, 4856– 4861
[11]Dongmei Mo, Xiangying Li, Yong Chen, Yang Jiang, ChunfangGan, Yuanfei Zhang, Weiguo Li, Yanmin Huang* , Jianguo Cui*, Fabrication and evaluation of slow-release lignin-based avermectin nano-delivery system with UV-shielding property. Scientifc Reports, (2021) 11:23248.
[12]J.-A. Xiao,(*) J.-L. Li, X.-L. Cheng, K. Chen, H. Peng, W.-Q. Chen, W. Su, Y.-M. Huang,(*) H. Yang,(*) Enantioselective formal [3+2]-cycloadditions to access spirooxindoles bearing four contiguous stereocenters through synergistic catalysis. Chem. Commun. 2021, 57, (36), 4456-4459.
[13]Wei Wu, Yan Wang,Jing Guo,Liu Cai,Yuan Chen,Yanmin Huang*, Yungui Peng,Asymmetric acyl Mannich reaction of isoquinolines with a(diazomethyl)phosphonate and diazoacetate catalyzed by chiral Brønsted acids,ChemComm,ChemComm,2020, DOI: 10.1039/d0cc03201h.
[14]Cui, J., Wei, M., Pang, L., Xiao, J.*, Gan, C., Guo, J.,Xie, C., Zhu, Q., Huang, Y.* Oxidative umpolung selenocyanation of ketones and arenes: An efficient protocol to the synthesis of selenocyanates.Tetrahedron,2020,76(10), 130978.
[15] J.-A. Xiao,(*) X.-L. Cheng, R.-F. Meng, X.-S. Qin, H. Peng, J.-W. Ren, Z.-Z. Xie, J.-G. Cui, Y.-M. Huang,(*) Straightforward Synthesis of 3-Selenocyanato-Substituted Chro- mones through Electrophilic Selenocyanation of Enaminones under Grinding Conditions. Synthesis 2020, 53, (05), 954-960.
[16]Yanmin Huang, Haiyan Wen, Jiahua Zheng, Chunfang Gan, Liping Pang, Chunling Pang, Xiaolan Liu, Junyan Zhan, Jianguo Cui*, Synthesis, Characterization, and Biological Evaluations of some steryl 2-methoxybenzoates as Anticancer Agents,Nat. Prod. Res.,2019, 33(8), 1101-1105.
[17]Y.M. Huang, Hu, Q., Cui, G., Guo, X., Wei, B., Gan, C.,Li, W. G., Mo, D. M., Lu, R., Cui, J.* Release-controlled microcapsules of thiamethoxam encapsulated in beeswax and their application in field.J. Environ. Sci. & Health, Part B,2019,1-13.
[18]Xiaoyun Li, Weiting Hu, Qiuju Xiong, Simin Ye,Yanmin Huang*, Qixiang Guo, Chiral Anion-Induced Catalytic Asymmetric Direct Dehydrative Coupling of 3-Vinylindoles and 3-Indolylmethanols, 2019, 361(8): 1803-1807,Adv. Synth. Catal. DOI: 10.1002/adsc.201.
[19]Jianguo Cui, Meizhen Wei, Liping Pang, Chunfang Gan, Junan Xiao, Haixin Shi, Junyan Zhan, Zhiping Liu,Yanmin Huang*, Synthesis and antiproliferative evaluation of novel steroidbenzisoselenazolone hybrids, Steroids, 2019, 152: 108502.
[20]JianGuo Cui, DongMei Mo, Yang Jiang, ChunFang Gan, WeiGuo Li, Ao Wu, Xiang-Ying Li, Jun-An Xiao, Qiang Hu, Hai-Yan Yuan, Rui Lu,YanMin Huang*,Fabrication, Characterization, and Insecticidal Activity Evaluation of Emamectin Benzoate-Sodium Lignosulfonate Nanoformulation with pH-responsive,Indus. Engin. Chem. Res. 2019, 58 (43), 19741-19751.
[21] Jianguo Cui, Liping Pang, Meizhen Wei, Chunfang Gan, Dandan Liu, Haiyan Yuan,Yanmin Huang*. Synthesis and antiproliferative activity of 17-[1′,2′,3′]-selenadiazolylpregnenolone compounds,Steroids,2018, 140, 151–158.
[22]Huang Yanmin, Zhao Dandan, Liu Chang, Gan Chunfang, Zhan Junyan, LinQifu, Shi Haixin, Cui Jianguo*. Rapid microwave assisted synthesis and antiproliferative evaluation of novel steroidal thiazole derivatives.Chem. Res. Chinese Uni.,2017, 2(33), 206-212.
[23]Yanmin Huang, Erbin Kong, Junyan Zhan, Shuang Chen, Chunfang Gan, Zhiping Liu, Liping Pang, Jianguo Cui*. Synthesis and Cytotoxic Evaluation of Steroidal Copper (Cu (II)) Complexes,Bioinorg. Chem. & Appl.,2017, Article ID 4276919, 6 pages; doi.org/10.1155/2017/4276919.
[24]Yanmin Huang, Chunhui Yang, Junyan Zhan, Chunfang Gan, Zhiping Liu, Chunling Pang, Haifeng Chen, Jianguo Cui*. Synthesis and antiproliferative activity of novel A-homo-B-norsteroid thiadiazole derivatives.Tetrahedron Lett.,2017, 58(30): 2952-2954.
[25]黄燕敏,戚斌斌,崔建国,甘春芳,杨春晖,刘畅,陈爽,石海信,某些B-降胆甾噻唑化合物的合成及抗肿瘤活性研究,有机化学,2016.3.01,(07):1602 - 1610。
[26]崔建国,刘畅,刘亮,甘春芳,卢艳,陈爽 ,董新,黄燕敏*,3-羟基-6-腙及6-羰基-3-腙胆甾烷的合成及抗肿瘤活性评估,有机化学,2016.12.15,36(12):2933-2940.
[27]崔建国 ,赵丹丹,何冬梅,黄燕敏*,刘志平,林啟福,石海信,甘春芳 ,去氢表雄酮噻唑衍生物的合成及抗肿瘤活性评估,有机化学,2016.03.15,36(3):630-637。
[28]Yanmin Huang ,Erbin Kong,Chunfang Gan,Zhiping Liu,Qifu Lin,Jianguo Cui*,Synthesis and Antiproliferative Activity of Steroidal Thiosemicarbazone Platinum (Pt(II)) Complexes,Bioinorganic Chemistry and Applications,2015,7:1-7。
[29]黄燕敏 ,姚秋翠,刘志平,甘春芳,郑嘉桦,盛海兵,石海信,崔建国(#),鹅脱氧胆酸含氮衍生物的合成及抗肿瘤活性研究,有机化学,2015,35:2168-2175。
[30]黄燕敏 ,刘亮,戚斌斌,赵丹丹,杨雷,甘春芳,崔建国*,7ß-羟基表雄酮的选择性合成,有机化学,2015,35(01):241-245。
[31]Jianguo Cui,Qifu Lin,Chunfang Gan,Junyan Zhan,Wei Su,Dandan Zhao,Binbin Qi,Yanmin Huang*,Synthesis and antiproliferative evaluation of some novelB-nor-D-homosteroids,Steroids,2015,98:138-142。
[32]Jianguo Cui ,Binbin Qi,Chunfang Gan,Zhipin Liu,Hu Huang,Dandan
Zhao,Yanmin Huang*,Synthesis and in Vitro Antiproliferative Evaluation of
Some B-norcholesteryl Benzimidazole and Benzothiazole Derivatives,marine drugs,2015,13:2488-2504。
[33]Jianguo Cui,Liang Liu,Dandan Zhao,Chunfang Gan,Xin Huang,Qi
Xiao,Binbin Qi,Lei Yang,Yanmin Huang*,Synthesis, characterization and
antitumor activities of some steroidal derivatives with side chain of 17-hydrazone aromatic heterocycle,Steroids,2015,95(95):32-38。
[34]Jianguo Cui*,Liang Liu,Dandan Zhao,Chunfang Gan,Xin Huang,Qi
Xiao,Binbin Qi,Lei Yang,Yanmin Huang*,Synthesis, characterization and antitumor activities of some steroidal derivatives with side chain of 17-hydrazone aromatic heterocycle,Steroids,2015,95(95):32-38。
[35]Yanmin Huang ,Qiucui Yao,Jianguo Cui*,Chunfang Gan,Qianyang Huang,Bing Su,Aimin Zhou,Syntheses of lactam derivatives of chenodeoxycholic acid and in vitro antiproliferative activity,Chemical Research in Chinese Universities,2014,30(4):605-613。
[36]Yanmin Huang ,Jianguo Cui*,Sijing Chen,Qifu Lin,Huacan Song,Chunfang Gan,Bin Su,Aimin Zhou,Synthesis and Evaluation of Some New Aza-B –homo cholestane Derivatives as Anticancer Agents,Mar.Drugs,2014,12(12):1715-1731。
[37]崔建国*,刘亮,甘春芳,肖琦,黄燕敏*,芳(杂)环甾体化合物的合成及生理活性研究,化学进展,2014,26(2/3):320-333。
[38]Chunfang Gan*,Qifu Lin,Jianguo Cui*,Jidan Feng,Jinni Guo,Huoying Liao,Yanmin Huang*,Synthesis and in vitro antiproliferative evaluation of some novel B-norcholesterols,Steroids,2014,79(79):37-43。
[39] Jianguo Cui*,Qifu Lin,Chunfang Gan,Qiucui Yao,Wei Su,Yanmin
Huang*,Synthesis and cytotoxic activity of some 4,6-diaza-A,B-dihomo-steroid
bilactams,Steroids,2014,79(79):14-18。
[40]Chunfang Gan,Jianguo Cui*,Shaoyang Su,Qifu Lin,Linyi Jia,Lianghua Fan,Yanmin Huang*,Synthesis and Antiproliferative Activity of Some Steroidal Thiosemicarbazones, Semicarbazones and Hydrozones. Steroids,Steroids,2014,87(87):99-107。
[41]Yanmin Huang ,Jianguo Cui*,Linyi Jia,Chunfang Gan,Huacan Song,Chun Zeng,Aimin Zhou,Synthesis and Evaluation of Some 17-Acetamido androstane and N,N-Dimethyl-7-deoxycholic Amide Derivatives as Cytotoxic Agents: Structure/ Activity Studies,Molecules,2013,18(18):7436-7447。
[42]Huang, Yanmin ,Cui, Jianguo ,Chen, Sijing,Gan, Chunfang,Yao*,Qiucui,Lin, Qifu,Synthesis and antiproliferative activity of C-homo-lactam derivatives of 7-deoxycholic acid,Bioorganic & Medicinal Chemistry Letters, 2013,23(7):2265-2267。
[43] Huang, Yanmin ,Cui, Jianguo* ,Li, Ying,Fan, Lei,Jiao,Yanxiao,Su, Shaoyang,Syntheses and antiproliferative activity of some sulfated hydroximino sterols,Medicinal Chemistry Research,2013,22(1):409-414。
[44]Huang, Yanmin ,Cui, Jianguo* ,Zheng, Qiaoxia,Zeng, Chun,Chen, Quan,Zhou, Aimin,6-Hydroximino-4-aza-A-homo-cholest-3-one and related analogue as a potent inducer of apoptosis in cancer cells,Steroids,2012,77(8-9):829-834。
[45]Huang Yanmin,Cui Jianguo ,Gan Chunfang,Yao Qiucui,Jia Linyi,
Steroidal Amides with Biological Activities,Progress in Chemistry, 2012,24(1):61-69
[46]林啟福,崔建国,甘春芳,刘亮,姚秋翠,黄燕敏*,海洋生物中具有生理活性的多羟基甾醇,有机化学,2012,(12):2214-2222。
[47]Yanmin Huang, Jianguo Cui*,Zhengguo Zhong,Chunfang Gan,Wenyan
Zhang,Huacan Song,Synthesis and Cytotoxicity of 7a-Aza-D-homo- androster -17 -one derivatives,Bioorg. Med. Chem. Lett.,2011,21(21):3641-3643。
[48]Yanmin Huang,Jianguo Cui*,Sijing Chen,Chunfang Gan,Aimin Zhou,Synthesis and antiproliferative activity of some steroidal lactams,Steroids,2011,76(76):1346-1350。
[49]Yanmin Huang ,Sijing Chen,Jianguo Cui*,Chunfang Gan,Zhiping Liu,Yingliang Wei,Huachan Song,Synthesis and cytotoxicity of A-homo-lactam derivatives of cholic acid and 7-deoxycholic acid,Steroids,2011,76(76):690-694。
[50]Huang Yanmin ,Li Ying,Cui Jianguo*,Wang Hui,Fan Lianghua,Synthes
is and Bioactivity of Sodium 3,6-Dihydroxy-5 alpha-steroid-3-sulfateds,Chinese Journal of Organic Chemistry, 2010,30(11):1689-1694。
[51]黄燕敏 ,苏绍烊,贾琳怡,甘春芳,林啟福,孔二斌,崔建国*,甾体肟醚化合物的合成及抗肿瘤活性研究,有机化学,2014,34(9):1816-1828。
[52]黄燕敏 ,苏绍烊,贾琳怡,甘春芳,林啟福,孔二斌,崔建国*,甾体肟醚化合物的合成及抗肿瘤活性研究,有机化学,2014,34(9):1816-1828。
[53]黄燕敏,李莹,崔建国,王辉,范良华,6-羟基-3-硫酸酯钠甾体化合物的合成及生理活性研究,有机化学,2010,(11):1689-1694。
[54]黄燕敏,崔建国,甘春芳,姚秋翠,贾琳怡, 具有生理活性的甾体酰胺类化合物,2012(1):61-69
二、专著
(1) 崔建国,黄燕敏,甘春芳,现代甾体化学,科学出版社,2014。
三、部分授权发明专利
(1) 黄燕敏,崔建国,赵丹丹,甘春芳,刘志平,4-(4’-三氟甲基)苯基-2-去氢表雄酮-17’-腙噻唑及其制备方法和用途,ZL 201510727195.4;
(2) 黄燕敏,崔建国,赵丹丹,甘春芳,刘志平,4-(4′-溴)苯基-2-雌酮-17′-腙噻唑及其制备方法和用途,ZL 201510725537.9;
(3)黄燕敏,崔建国,焦艳晓,甘春芳,甾体锌金属配合物及其制备方 法和在制备抗肿瘤药物中的应,用,ZL 201310184359.4;
(4)黄燕敏,林启福,崔建国,甘春芳,肖琦,刘亮,一类具[6-5-6-6]甾核结构的 B-降-D-homo-内酰胺甾体化合 物的合成方法,ZL201310184259.1;
(5)崔建国,莫冬梅,黄燕敏,李卫国,江杨,李香荧,甘芳,卢瑞, 一种以木质素为包裹基质的纳米抗光解控释农药及其制备方法, ZL 201911075226.7;
(6)展军颜,甘春芳,黄燕敏,刘钦洲,黄晓彤,喹啉化鹅去氧胆酸传感器及其合成方法和应用,ZL 201911309381.0;
(7) 崔建国,莫冬梅,黄燕敏,梁奕强,江杨,零春华,覃建才,刘玉生,卢瑞, 一种甲维盐纳米颗粒抗光解缓释农药及制备方法,ZL 201810980535.8;
(8) 甘春芳,祝志凌,刘志平,黄燕敏,崔建国, 3-生物素醚酯-B降-胆甾苯并咪唑化合物及其制备方法和应用,ZL 2018011108808.6;
(9) 甘春芳,陈华龙,庞婷婷,黄晓彤,刘钦洲,黄燕敏, 17-酰胺雌甾类化合物及其制备方法和应用,ZL 202010488839.X;
(10)甘春芳,盛海兵,黄燕敏,展军颜,崔建国,刘晓兰,2-(3’-17’-孕甾烷基)-5-氟苯并咪唑的合成方法,ZL 201710736902.5;
(11)甘春芳,董新,崔建国,展军颜,黄燕敏,苯基取代噻二唑类噻唑啉酮化合物及其制备方法和应用,ZL 201710932055.X;
(12)甘春芳,董新,崔建国,展军颜,黄燕敏,苯基取代噻二唑类噻唑啉酮化合物及其制备方法和应,ZL 201710932055.X;
(13)崔建国,黄燕敏,庞丽萍,甘春芳,展军颜,有机硒化合物的制备方法,ZL 201810088954;
(14)崔建国,黄燕敏,杨春晖,展军颜,甘春芳,刘志平,用于抗肿瘤的化合物及其制备方法和用途;ZL201611209521.3
(15)甘春芳,董新,展军颜,盛海兵,崔建国,黄燕敏,22-降-豆甾苯并咪唑化合物及其制备方法和应用,ZL 2016102446497
(16)崔建国,刘亮,黄燕敏, 甘春芳,肖琦,黄新,孕烯醇酮芳香醛吖嗪甾体化合 物及其合成方法和在制备抗肿 瘤药物中的应用ZL 201310184358.X;
(17)崔建国,戚斌斌,黄燕敏,甘春芳,刘志平,一种B-降胆甾烷苯并咪唑类化合物及其制备方法和用途,ZL 201410786854.7;
(18)崔建国,刘亮,黄燕敏,甘春芳,肖琦,孔二斌,去氢表雄酮芳香醛吖嗪甾体化合物及其合成方法和在制备抗肿瘤药物中的应用,ZL 201310184257.2;
(19)崔建国,刘亮,黄燕敏,甘春芳,黄珊,林启福,3-羟基胆甾-6-酮芳香醛吖嗪甾 体化合物及其合成方法和在制 备抗肿瘤药物中的应用,ZL 201310186120.0;
(20)崔建国,范良华,甘春芳,黄燕敏,B-降-3,6-二取代胆甾烷化合物 及其制备方法和在制备抗肿瘤 药物中的应用,ZL 201110 179146.3;
(21)崔建国,黄燕敏,周爱民,6-取代-4-氮杂-A-homo-3-氧代甾体化合物及其在制备抗肿瘤药物中的应用,ZL 201010107528.0
四、获得学术奖励
(1)黄燕敏(1/5), 具有扩环及缩环甾核结构甾体化合物作为抗肿瘤药物的合成和评估,广西壮族自治区人民政府,自然科学,省部三等奖,2016。(黄燕敏、崔建国、甘春芳、林啟福、陈思静、姚秋翠)
(2)黄燕敏(2/5),具有抗肿瘤活性甾体硫酸酯钠盐及肟类化合物的合成及抗肿瘤活性评估,广西壮族自治区人民政府,自然科学,省部二等奖,2011。(崔建国,黄燕敏,甘春芳,范磊,王辉)
(3)黄燕敏(5/5)具有抗肿瘤活性多羟基甾醇的合成研究,广西壮族自治区人民政府,自然科学,省部三等奖,2004,(崔建国,曾陇梅,苏境娱,何小玉,黄燕敏)
(4)黄燕敏(2/5)甾体化合物作为抗肿瘤药物的结构修饰改造,广西壮族自治区人民政府,自然科学,省部三等奖,2021(甘春芳,黄燕敏,崔建国,展军颜,刘志平)