袁静梅

学历、职称：博士/博士后、副教授、硕士生导师(有机化学/材料与化工)

研究方向：（1）有机小分子药物的设计、合成及其抗肿瘤活性研究；

（2）具有药理活性的有机功能材料绿色制备；

（3）以G-四链体及其解旋酶为靶点的药物化学与化学生物学研究。

Email：yuanjm9@nnnu.edu.cn

教育与研究经历

2022.06~至今：南宁师范大学，化学与材料学院，专任教师（副教授）；

2020.05~2022.05：中山大学，药学院，博士后；

2016.09~2019.12：广西师范大学，化学与药学学院，理学博士学位；

2013.09~2016.06：广西师范大学，化学与药学学院，理学硕士学位。

教学情况

主讲《无机化学》、《无机及分析化学》、《无机化学实验》和《化学学科前沿》等多门本科生课程。

主持承担科研项目

（1）广西壮族自治区第一批青苗人才资助项目，主持，在研。

（2）南宁师范大学博士科研启动基金项目，主持，在研。

（3）广西自然科学基金面上项目：2025.03~2028.02，主持，在研。

（4）广西自然科学基金青年科学基金项目：2023.06~2026.05，主持，在研。

（5）广东省基础与应用基础研究基金自然科学基金项目面上项目，2021.01~2023.12，主持，结题。

（6）中国博士后科学基金第68批面上项目，2021.01~2022.06，主持，结题。

主要学术成果（^#共同第一作者，*通讯作者）

[1] Jun Huang, Fengting Zhu, Jinlian Wen, Jiali Xu, Jing-Mei Yuan*, Wenqiang Chen*. Merging 2,3-butanedione and N-hydroxysuccinimide as visible-light-enabled hydrogen atom transfer catalysts for C=C double bond cleavage of 2-cyanoaryl acrylamides toward the synthesis of 4-amino-2-quinolones. Org. Chem. Front., 2024, 11, 3855–3860.

[2] Jun Huang, Caijin Ban, Jiangping Qin, Jiali Xu, Yunqiong Gu, Liang Wei*, Jing-Mei Yuan*， Guobao Huang*. Visible-light promoted radical cascade cyclization of 3-allyl-2-arylquinazolinones for the synthesis of phosphorylated dihydroisoquinolino[1,2-b]quinazolinones. Chem. Commun., 2024, 60, 8119–8122.

[3] Li-Ting Zhong^#, Jing-Mei Yuan^#, Wen-Li Fu, Zi-Lin Zhang, Xiaoya Li, Tian-Miao Ou, Jia-Heng Tan*, Zhi-Shu Huang, Shuo-Bin Chen*. Identification of sanguinarine as c-MYC transcription inhibitor through enhancing the G-quadruplex-NM23-H2 interactions. Bioorg. Chem., 2024, 153, 107842–107852.

[4] Feifei Chen^#, Suju Jiang^#, Qiaozhi Zhou, Siqi Chen, Zihua Wu*, Yuyang Guo, Anhua Wei, Jingmei Yuan*, Guobao Huang*. Synthesis of small-sized gold nanorod using catechol as a reducing agent. Optical Materials, 2023, 145, 114497.

[5] Mao-Lin Li^#, Jing-Mei Yuan^#, Hao Yuan, Bi-Han Wu, Shi-Liang Huang, Qing-Jiang Li, Tian-Miao Ou, Hong-Gen Wang, Jia-Heng Tan, Shuo-Bin Chen* and Zhi-Shu Huang*. Design, Synthesis, and Evaluation of New Sugar-Substituted Imidazole Derivatives as Selective c-MYC Transcription Repressors Targeting the Promoter G-Quadruplex. J. Med. Chem. 2022, 65, 12675.

[6] Guo-Hai Zhang^#, Jing-Mei Yuan^#, Gang Qian, Chen-Xi Gu, Kai Wei, Dong-Liang Mo, Jiang-Ke Qin, Yan Peng, Zu-Ping Zhou, Cheng-Xue Pan^*, Gui-Fa Su^*. Phthalazino[1,2‑b]quinazolinones as p53 activators: cell cycle arrest, apoptotic response and Bak−Bcl-xl complex reorganization in bladder cancer cells. J. Med. Chem. 2017, 60, 6853.

[7] Jing-Mei Yuan^#, Kai Wei^#, Guo-Hai Zhang, Nan-Ying Chen, Xin-Wei Wei, Cheng-Xue Pan^*, Dong-Liang Mo^*, Gui-Fa Su^*. Cryptolepine-Aromathecins-based mimics as potent DNA-cleavage and anticancer agents: design, synthesis and DNA targeting-induced apoptosis. Eur. J. Med. Chem. 2019, 169, 144.

[8] Xin-Wei Wei^#, Jing-Mei Yuan^#, Guo-Hai Zhang, Cheng-Xue Pan^*, Dong-Liang Mo^*, Gui-Fa Su^*. 2-Styryl-4-aminoquinazoline derivatives as potent DNA-cleavage, p53-activation and in vivo effective anticancer agents. Eur. J. Med. Chem. 2020, 186, 111851.

[9] Jing-Mei Yuan^#, Jinnan Li^#, Heyang Zhou^#, Jiali Xu, Fengting Zhu, Qiuli Liang, Zhiping Liu, Guobao Huang^*, Jun Huang^*. Synthesis of 3-sulfonylquinolines by visible-light promoted metal-free cascade cycloaddition involving N-propargylanilines and sodium sulfinates. New J. Chem. 2020, 44, 3189.

[10] Jing-Mei Yuan^#, Nan-Ying Chen^#, Hao-Ran Liao, Guo-Hai Zhang, Xiao-Juan Li, Zi-Yu Gu, Cheng-Xue Pan^*, Dong-Liang Mo^*, Gui-Fa Su^*. 3-(Benzo[d]thiazol-2-yl)-4-aminoquinolin -e derivatives as novel scaffold topoisomerase I inhibitor via DNA intercalation: design, synthesis, and antitumor activities. New J. Chem. 2020, 44, 11203.

[11] Guo-Xue He^#, Jing-Mei Yuan^#, Hai-Miao Zhu, Kai Wei, Ling-Yun Wang, Shi-Lin Kong, Dong-Liang Mo, Cheng-Xue Pan^*, Gui-Fa Su^*. Synthesis and antitumor evaluation of 2,3-diarylbenzofuran derivatives on HeLa cells. Bioorg. Med. Chem. Lett. 2017, 27, 1660.

[12] Congyu Li^#, Jing-Mei Yuan^#, Wenqiang Chen, Yimiao He, Jun Huang, Yanmin Huang, Qi Xiao, Jiarong Sheng, and Chusheng Huang. Defluorinative C(sp³)-P Bond Construction for the Synthesis of Phosphorylation gem-Difluoroalkenes under Catalyst- and Oxidant-Free Conditions. Chemistry-An Asian journal 2019, 14, 2584.