黄燕敏

发布者:黄燕敏 [发表时间]:2024-03-12 [来源]:南宁师范大学化学与材料学院 [浏览次数]:
图片 校对 陆胜文
审核 杨晶

黄燕敏

学历、职称:博士生/兼职博士生导师

研究方向 药物合成 有机合成 纳米农药

专业方向:有机化学

联系方式:联系电话:13977159868, 电子邮箱:huangyanmin828@163.com

教育与研究经历

教育经历

1991/9–1995/7,兰州大学,有机化学,学士

2001/9–2004/7,广西师范学院(现南宁师范大学),有机化学, 硕士

2008/9–2011/12,中山大学,有机化学,博士

2012/5-2015/11,美国克利夫兰州立大学访学

1995/7-至今,南宁师范大学,化学与材料科学学院,教授

(简介)长期从事甾体化合物结构修饰及生理活性研究、具有抗肿瘤活性甾体化合物的作用机制研究、高效新型农药的研发工作。以第一作者或通讯作者在Chemcal CommunicationsOrganic Chemistry FrontiersAdvanced Synthesis & CatalysisTetrahedronSteroidsBioorg. Med. Chem. Lett.等国际刊物上以第一作者或通讯作者发表SCI论文60多篇。获国家授权发明专利16项。2004 年参与完成的科研成果具有抗肿瘤活性多羟基甾醇的合成 研究获广西科技进步三等奖(排名第五); 2011年作为主要完成人参与的具有抗肿瘤活性甾体硫酸酯钠盐及肟类化合物的合成及抗肿瘤活性评估2011 年获广西自然科学奖二等奖(排名第二);2016 年,作为第一完成人完成的项目具有扩环及缩环甾核结构甾体化合物作为抗肿瘤药物的合成和评估获得广西自然科学奖三等奖。主持国家级、省级及各类项目10余项,2013年入选广西高等学校优秀中青年骨干教师培养工程第二期培养对象、2015年入选广西中青年科技工作者、2017年入选广西十百千人才工程第二层次人选2020年入选广西高校卓越学者。

教学情况

有机化学国家一流专业负责人,主讲有机化学”“有机化学实验”“有机合成本科生及研究生课程。

荣誉称号

12020年入选广西高校卓越学者

12017年获第二十批广西十百千人才工程第二层次人选

22015年获第十三届广西青年科技奖入选者

32013入选广西高等学校优秀中青年骨干教师培养工程

42014广西师范学院学科带头人

52015年度广西师范学院科研工作先进个人

承担项目与课题

(1)国家自然科学基金地区基金项目,21462009,具有特殊甾核结构甾体杂环化合物的设计合成及生物活性评估, 2015/01-2018/1250万元, 已提交结题报告,主持;

(2)广西重点研发项目,桂科AB21220015, 绿色环保物理作用机制(窒息)害螨灭杀剂的研究开发,135万,在研,主持;

(3)广西创新发展专项(科技重大专项)项目(子课题一),环保控释农药的制备技术研究与产业化,113.4万元,在研,主持;

4广西自然科学基金面上项目,2018JJA120087,新型甾体硒杂环化合物的设计、合成及生理活性研究,2019.1-2011.12,12万,在研,主持;

5南宁市科技开发项目,20171125-5,广西甾体药物生物工程技术研究中心建设,2017/1- 2018/12, 30万元,在研,主持;

6)广西自然科学基金项目,2014GXNSFAA118052,北部湾海洋生物中靶向 Src 新型抗肿瘤药物先导的识别及结构优化,2014/06-2017/05, 5万元,结题,主持;

7)南宁市科技开发项目,20145203,提高无内吸性农药药效及导向剂技术开发,2015.03-2017.03,结题,主持;

8)广西高等学校科研项目,201202ZD059,抗肿瘤甾体金属配合物的合成及生理活性研究,2012.03-2014.03, 7万元,结题,主持;

9)南宁市科技开发项目,20131091,蔗糖硫酸酯金属盐作为杀菌消毒液,抗菌剂及抗菌材料的研发,2013.01-2014.12, 25万元,结题,主持;

10)南宁市科技开发项目,20131091,蔗糖硫酸酯金属盐作为杀菌消毒液,抗菌剂及抗菌材料的研发,2013.01-2014.12, 25万元,结题,主持;

11)广西自然科学基金项目,2010GXNSFA013052,海洋生物活性分子的改性和应用甾合铂配合物的合成及生理活性研究,2010.03-2013.034万元,结题,主持8.横向课题,具有内吸性农药的合成,2014/1-2016/1,6万元,结题,主持;

12)广西高等学校优秀中青年骨干教师培养工程(第一期),2013.12- 2016.12,18

13)国家自然科学基金地区基金项目,21562007, B-Nor甾体化合物抗肿瘤机制及药物靶点的研究,2016.01-2019.1240万元,在研,参加

14)广西自然科学基金项目,2010GXNSFD013019,甾体内酰胺化合物的合成、表征及抗肿瘤活性研究,2010.03-2013.03,结题,参加

15)国家自然科学基金地区基金项目,20562001,海洋生物中具有抗肿瘤和抗病毒活性的多羟基甾醇及其硫酸酯钠盐的合成和它们的构效关系研究2006.01- 2008.1220万,结题,参加

学术成果

主要学术论文(* 通讯作者)

  1. Yanmin Huang, Xiangying Li, Dongmei Mo, Haiyan Yuan, Qiang Hu,

    Yang Jiang, Chunfang Gan, Yong Chen, Weiguo Li, Rui Lu, and Jianguo Cui, Fabrication and evaluation of Lambda-Cyhalothrin nanosuspoemulsion with pH- and temperature-responsive based on polyethylene wax as carrier,J. Environ. Sci. & Health, Part B, 2021,56(8):741-752.

    [2]Yimiao He,* XueXue Chang, Zhongfu Su, Kun Liu, Yanmin Huang,* Chusheng Huang, Jian Lei* and Qiang Zhu, Tunable Synthesis of Chalcophosphinic Amides and Tertiary  Phosphinates Using tert-Butyl N, N-Dialkylperoxyamidate, Org. Chem. Front., 2021, 8, 4860.

    [3]Yuan Chen, Rui Yu,Min Wang,Yanmin Huang,*Yungui Peng, Enantioselective 1,6-Conjugate Addition of Dialkyl α-Diazo Methylphosphonateto para-Quinone Methides,Adv. Synth. Catal. 2021, 363, 4856– 4861

    [4]Dongmei Mo, Xiangying Li, Yong Chen, Yang Jiang, ChunfangGan, Yuanfei Zhang, Weiguo Li, Yanmin Huang* , Jianguo Cui*, Fabrication and evaluation of slow-release lignin-based avermectin nano-delivery system with UV-shielding property. Scientifc Reports, (2021) 11:23248.

    [5]J.-A. Xiao,(*) J.-L. Li, X.-L. Cheng, K. Chen, H. Peng, W.-Q. Chen, W. Su, Y.-M. Huang,(*) H. Yang,(*) Enantioselective formal [3+2]-cycloadditions to access spirooxindoles bearing four contiguous stereocenters through synergistic catalysis. Chem. Commun. 2021, 57, (36), 4456-4459.

    [6]Wei Wu, Yan Wang,Jing Guo,Liu Cai,Yuan Chen,Yanmin Huang* Yungui PengAsymmetric acyl Mannich reaction of isoquinolines with a(diazomethyl)phosphonate  and diazoacetate catalyzed by chiral Brønsted acidsChemCommChemComm,2020, DOI: 10.1039/d0cc03201h.

    [7]Cui, J., Wei, M., Pang, L., Xiao, J.*, Gan, C., Guo, J.,Xie, C., Zhu, Q., Huang, Y.* Oxidative umpolung selenocyanation of ketones and arenes: An efficient protocol to the synthesis of selenocyanates.Tetrahedron,2020,76(10), 130978.

    [8] J.-A. Xiao,(*) X.-L. Cheng, R.-F. Meng, X.-S. Qin, H. Peng, J.-W. Ren, Z.-Z. Xie, J.-G. Cui, Y.-M. Huang,(*) Straightforward Synthesis of 3-Selenocyanato-Substituted Chro- mones through Electrophilic Selenocyanation of Enaminones under Grinding Conditions. Synthesis 2020, 53, (05), 954-960.

    [9]Yanmin Huang, Haiyan Wen, Jiahua Zheng, Chunfang Gan, Liping Pang, Chunling Pang, Xiaolan Liu, Junyan Zhan, Jianguo Cui*, Synthesis, Characterization, and Biological Evaluations of some steryl 2-methoxybenzoates as Anticancer Agents,Nat. Prod. Res.,2019, 33(8), 1101-1105.

    [10]Y.M. Huang, Hu, Q., Cui, G., Guo, X., Wei, B., Gan, C.,Li, W. G., Mo, D. M., Lu, R., Cui, J.* Release-controlled microcapsules of thiamethoxam encapsulated in beeswax and their application in field.J. Environ. Sci. & Health, Part B,2019,1-13.

    [11]Xiaoyun Li, Weiting Hu, Qiuju Xiong, Simin Ye,Yanmin Huang*, Qixiang Guo, Chiral Anion-Induced Catalytic Asymmetric Direct Dehydrative Coupling of 3-Vinylindoles and 3-Indolylmethanols, 2019, 361(8): 1803-1807Adv. Synth. Catal. DOI: 10.1002/adsc.201.

    [12]Jianguo Cui, Meizhen Wei, Liping Pang, Chunfang Gan, Junan Xiao, Haixin Shi, Junyan Zhan, Zhiping Liu,Yanmin Huang*, Synthesis and antiproliferative evaluation of novel steroidbenzisoselenazolone hybrids, Steroids, 2019, 152: 108502.

    [13]JianGuo Cui, DongMei Mo, Yang Jiang, ChunFang Gan, WeiGuo Li, Ao Wu, Xiang-Ying Li, Jun-An Xiao, Qiang Hu, Hai-Yan Yuan, Rui Lu,YanMin Huang*,Fabrication, Characterization, and Insecticidal Activity Evaluation of Emamectin Benzoate-Sodium Lignosulfonate Nanoformulation with pH-responsive,Indus. Engin. Chem. Res. 2019, 58 (43), 19741-19751.

    [14] Jianguo Cui, Liping Pang, Meizhen Wei, Chunfang Gan, Dandan Liu, Haiyan Yuan,Yanmin Huang*. Synthesis and antiproliferative activity of 17-[1′,2′,3′]-selenadiazolylpregnenolone compounds,Steroids,2018, 140, 151–158.

    [15]Huang Yanmin, Zhao Dandan, Liu Chang, Gan Chunfang, Zhan Junyan, LinQifu, Shi Haixin, Cui Jianguo*. Rapid microwave assisted synthesis and antiproliferative evaluation of novel steroidal thiazole derivatives.Chem. Res. Chinese Uni.,2017, 2(33), 206-212.

    [16]Yanmin Huang, Erbin Kong, Junyan Zhan, Shuang Chen, Chunfang Gan, Zhiping Liu, Liping Pang, Jianguo Cui*. Synthesis and Cytotoxic Evaluation of Steroidal Copper (Cu (II)) Complexes,Bioinorg. Chem. & Appl.,2017, Article ID 4276919, 6 pages; doi.org/10.1155/2017/4276919.

    [17]Yanmin Huang, Chunhui Yang, Junyan Zhan, Chunfang Gan, Zhiping Liu, Chunling Pang, Haifeng Chen, Jianguo Cui*. Synthesis and antiproliferative activity of novel A-homo-B-norsteroid thiadiazole derivatives.Tetrahedron Lett.,2017, 58(30): 2952-2954.

    [18]黄燕敏,戚斌斌,崔建国,甘春芳,杨春晖,刘畅,陈爽,石海信,某些B-降胆甾噻唑化合物的合成及抗肿瘤活性研究,有机化学,2016.3.01,(07):1602 - 1610

    [19]崔建国,刘畅,刘亮,甘春芳,卢艳,陈爽 ,董新,黄燕敏*,3-羟基-6-腙及6-羰基-3-腙胆甾烷的合成及抗肿瘤活性评估,有机化学,2016.12.153612):2933-2940.

    [20]崔建国 ,赵丹丹,何冬梅,黄燕敏*,刘志平,林啟福,石海信,甘春芳 ,去氢表雄酮噻唑衍生物的合成及抗肿瘤活性评估,有机化学,2016.03.15363):630-637

    [21]Yanmin Huang Erbin KongChunfang GanZhiping LiuQifu LinJianguo Cui*Synthesis and Antiproliferative Activity of Steroidal Thiosemicarbazone Platinum (Pt(II)) ComplexesBioinorganic Chemistry and Applications201571-7

    [22]黄燕敏 ,姚秋翠,刘志平,甘春芳,郑嘉桦,盛海兵,石海信,崔建国(#),鹅脱氧胆酸含氮衍生物的合成及抗肿瘤活性研究,有机化学,2015352168-2175

    [23]黄燕敏 ,刘亮,戚斌斌,赵丹丹,杨雷,甘春芳,崔建国*7ß-羟基表雄酮的选择性合成,有机化学,20153501):241-245

    [24]Jianguo CuiQifu LinChunfang GanJunyan ZhanWei SuDandan ZhaoBinbin QiYanmin Huang*Synthesis and antiproliferative evaluation of some novelB-nor-D-homosteroidsSteroids201598138-142

    [25]Jianguo Cui Binbin QiChunfang GanZhipin LiuHu HuangDandan

    ZhaoYanmin Huang*Synthesis and in Vitro Antiproliferative Evaluation of

    Some B-norcholesteryl Benzimidazole and Benzothiazole Derivativesmarine drugs2015132488-2504

    [26]Jianguo CuiLiang LiuDandan ZhaoChunfang GanXin HuangQi

    XiaoBinbin QiLei YangYanmin Huang*Synthesis, characterization and

    antitumor activities of some steroidal derivatives with side chain of 17-hydrazone aromatic heterocycleSteroids20159595):32-38

    [27]Jianguo Cui*Liang LiuDandan ZhaoChunfang GanXin HuangQi

    XiaoBinbin QiLei YangYanmin Huang*Synthesis, characterization and antitumor activities of some steroidal derivatives with side chain of 17-hydrazone aromatic heterocycleSteroids20159595):32-38

    [28]Yanmin Huang Qiucui YaoJianguo Cui*Chunfang GanQianyang HuangBing SuAimin ZhouSyntheses of lactam derivatives of chenodeoxycholic acid and in vitro antiproliferative activityChemical Research in Chinese Universities2014304):605-613

    [29]Yanmin Huang Jianguo Cui*Sijing ChenQifu LinHuacan SongChunfang GanBin SuAimin ZhouSynthesis and Evaluation of Some New Aza-B –homo cholestane Derivatives as Anticancer AgentsMar.Drugs20141212):1715-1731

    [30]崔建国*,刘亮,甘春芳,肖琦,黄燕敏*,芳()环甾体化合物的合成及生理活性研究,化学进展,2014262/3):320-333

    [31]Chunfang Gan*Qifu LinJianguo Cui*Jidan FengJinni GuoHuoying LiaoYanmin Huang*Synthesis and in vitro antiproliferative evaluation of some novel B-norcholesterolsSteroids20147979):37-43

    [32] Jianguo Cui*Qifu LinChunfang GanQiucui YaoWei SuYanmin

    Huang*Synthesis and cytotoxic activity of some 4,6-diaza-A,B-dihomo-steroid

    bilactamsSteroids20147979):14-18

    [33]Chunfang GanJianguo Cui*Shaoyang SuQifu LinLinyi JiaLianghua FanYanmin Huang*Synthesis and Antiproliferative Activity of Some Steroidal Thiosemicarbazones, Semicarbazones and Hydrozones. SteroidsSteroids20148787):99-107

    [34]Yanmin Huang Jianguo Cui*Linyi JiaChunfang GanHuacan SongChun ZengAimin ZhouSynthesis and Evaluation of Some 17-Acetamido androstane and N,N-Dimethyl-7-deoxycholic Amide Derivatives as Cytotoxic Agents: Structure/ Activity StudiesMolecules20131818):7436-7447

    [35]Huang, Yanmin Cui, Jianguo Chen, SijingGan, ChunfangYao*,QiucuiLin, QifuSynthesis and antiproliferative activity of C-homo-lactam derivatives of 7-deoxycholic acidBioorganic & Medicinal Chemistry Letters, 2013237):2265-2267

    [36] Huang, Yanmin Cui, Jianguo* Li, YingFan, LeiJiao,YanxiaoSu, ShaoyangSyntheses and antiproliferative activity of some sulfated hydroximino sterolsMedicinal Chemistry Research2013221):409-414

    [37]Huang, Yanmin Cui, Jianguo* Zheng, QiaoxiaZeng, ChunChen, QuanZhou, Aimin6-Hydroximino-4-aza-A-homo-cholest-3-one and related analogue as a potent inducer of apoptosis in cancer cellsSteroids2012778-9):829-834

    [38]Huang YanminCui Jianguo Gan ChunfangYao QiucuiJia Linyi

    Steroidal Amides with Biological ActivitiesProgress in Chemistry, 2012,24(1):61-69

    [39]林啟福,崔建国,甘春芳,刘亮,姚秋翠,黄燕敏*,海洋生物中具有生理活性的多羟基甾醇,有机化学,2012,(12):2214-2222

    [40]Yanmin Huang, Jianguo Cui*Zhengguo ZhongChunfang GanWenyan

    ZhangHuacan SongSynthesis and Cytotoxicity of 7a-Aza-D-homo- androster -17 -one derivativesBioorg. Med. Chem. Lett.20112121):3641-3643

    [41]Yanmin HuangJianguo Cui*Sijing ChenChunfang GanAimin ZhouSynthesis and antiproliferative activity of some steroidal lactamsSteroids20117676):1346-1350

    [42]Yanmin Huang Sijing ChenJianguo Cui*Chunfang GanZhiping LiuYingliang WeiHuachan SongSynthesis and cytotoxicity of A-homo-lactam derivatives of cholic acid and 7-deoxycholic acidSteroids20117676):690-694

    [43]Huang Yanmin Li YingCui Jianguo*Wang HuiFan LianghuaSynthes

    is and Bioactivity of Sodium 3,6-Dihydroxy-5 alpha-steroid-3-sulfatedsChinese Journal of Organic Chemistry, 20103011):1689-1694

    [44]黄燕敏 ,苏绍烊,贾琳怡,甘春芳,林啟福,孔二斌,崔建国*,甾体肟醚化合物的合成及抗肿瘤活性研究,有机化学,2014349):1816-1828

    [45]黄燕敏 ,苏绍烊,贾琳怡,甘春芳,林啟福,孔二斌,崔建国*,甾体肟醚化合物的合成及抗肿瘤活性研究,有机化学,2014349):1816-1828

    [46]黄燕敏,李莹,崔建国,王辉,范良华,6-羟基-3-硫酸酯钠甾体化合物的合成及生理活性研究,有机化学,2010,(11):1689-1694

    [47]黄燕敏,崔建国,甘春芳,姚秋翠,贾琳怡, 具有生理活性的甾体酰胺类化合物,2012(1):61-69

    二、专著

    (1) 崔建国,黄燕敏,甘春芳,现代甾体化学,科学出版社,2014

    三、部分授权发明专利

    (1) 崔建国,刘亮,黄燕敏,甘春芳,黄珊,林启福,3-羟基胆甾-6-酮芳香醛吖嗪甾体化合物及其合成方法和在制备抗肿瘤药物中的应用,ZL 201310186120.0

    (2) 黄燕敏,林启福,崔建国,甘春芳,肖琦,刘亮,一类具有[6-5-6-6]甾核结构的B--D-homo-内酰胺甾体化合物的合成方法, ZL 201310184259.1

    (3) 崔建国,范良华,甘春芳,黄燕敏,B--3,6-二取代胆甾烷化合物及其制备方法和在制备抗肿瘤药物中的应用, ZL 201110179146.3

    (4) 崔建国,黄燕敏,周爱民,6-取代-4-氮杂-A-homo-3-氧代甾体化合物及其在制备抗肿瘤药物中的应用, ZL 201010107528.0

    (5) 崔建国,黄燕敏,周爱民, 6-取代-4-氮杂-A-homo-3-氧代甾体化合物及其在制备抗肿瘤药物中的应用, ZL 201010107528.0

    (6)黄燕敏,崔建国,焦艳晓,甘春芳,甾体锌金属配合物及其制备方法和在抗肿瘤药物中的应用,ZL 201310184359.4

    (7) 崔建国,戚斌斌,黄燕敏,甘春芳,刘志平,一种B-降胆甾烷苯并咪唑类化合物及其制备方法和用途, ZL 201410786854.7

    (8) 崔建国,戚斌斌,黄燕敏,甘春芳,刘志平,一种B-降胆甾烷苯并咪唑类化合物及其制备方法和用途,中国,ZL 201410786854.7

    四、获得学术奖励

    1黄燕敏1/5, 具有扩环及缩环甾核结构甾体化合物作为抗肿瘤药物的合成和评估,广西壮族自治区人民政府,自然科学,省部三等奖,2016。(黄燕敏、崔建国、甘春芳、林啟福、陈思静、姚秋翠)

    2黄燕敏(2/5),具有抗肿瘤活性甾体硫酸酯钠盐及肟类化合物的合成及抗肿瘤活性评估,广西壮族自治区人民政府,自然科学,省部二等奖,2011。(崔建国,黄燕敏,甘春芳,范磊,王辉)

    3黄燕敏5/5)具有抗肿瘤活性多羟基甾醇的合成研究,,广西壮族自治区人民政府,自然科学,省部三等奖,2004,(崔建国,曾陇梅,苏境娱,何小玉,黄燕敏